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. 2021 Feb 25;11(3):346. doi: 10.3390/biom11030346

Figure 1.

Figure 1

A novel cascade for the biosynthesis of non-natural deoxyribonucleotides: The adenine phosphoribosyltransferase (APT) catalyzes the loading of the nucleobase 2Cl-adenine on the ribose moiety in the form of phosphoribosyl pyrophosphate (PRPP). The polyphosphate kinase (PPK) performs two consecutive phosphorylation reactions to form 2Cl-adenosine triphosphate. The ribonucleotide reductase (RNR) catalyze the reduction to the final product 2Cl-deoxyadenosine-triphosphate.