Figure 4.

Diminished glycoprotein expression in the glaucomatous optic nerve of HET animals. Comparison of ECM glycoprotein expression in optic nerves of WT and HET mice was revealed by RT-qPCR analyses. Significantly higher Fn1 and Tnc expression levels were observed in the optic nerves of HET compared to WT mice. Comparable mRNA levels were found for Tnr and Lamc3. In contrast, the expression of Lama4 and Lamb2 was significantly downregulated in the optic nerves of HET compared to WT mice. Groups were compared using a pairwise fixed reallocation and randomization test. Data are shown as median ± quartile ± minimum/maximum. * p < 0.05, ** p < 0.01. n = 5/group.