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. 2021 Feb 24;10(3):169. doi: 10.3390/biology10030169

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Increased signal area of the 473HD epitope/phosphacan in the glaucomatous optic nerve. Most representative immunohistochemical ECM stainings are shown. Aggrecan (green; (A,B)), brevican (green; (D,E)), phosphacan (green; (G,H)) as well as all RPTPβ/ζ isoforms (red; (J,K)) showed an immunostaining throughout the optic nerve tissue. Detection of cell nuclei by TO-PRO-3 (blue). Quantification revealed a significant increase in the phosphacan⁺ area in the glaucomatous HET optic nerve (I). Comparable signals for all RPTPβ/ζ isoforms (L), aggrecan (C) and brevican (F) were found in both genotypes. Groups were analyzed by Student‘s t-test. Data are shown as mean ± SEM ± SD. * p < 0.05. n = 5/group. Scale bar = 50 μm.