Table 4.

Facts and myths about high-dose intravenous vitamin C (IVC) effectiveness in advanced-stage cancer patients.

Myths	Facts
High-dose IVC is a potent anticancer treatment because of its proven effectiveness in preclinical in vitro and animal studies	No consistent evidence for anti-cancer efficacy of high dose IVC therapy in patients with advanced-stage cancer in terms of objective tumor-related response or improved survival outcomes.
High-dose IVC treatment enhances effectiveness of conventional anticancer therapy	No reliable evidence for increased effectiveness of combined IVC/conventional therapy compared to standard chemotherapy.
High-dose IVC treatment reduces chemotherapy-induced toxicity	No reliable evidence for decreased chemotherapy-induced toxicity after combined IVC/conventional therapy compared to standard chemotherapy.
High-dose IVC reduces fatigue in cancer patients	Positive effect of high-dose IVC on cancer-related fatigue comprises various factors and it can be more expressed in patients with basically better performance status and in those with chemotherapy-related fatigue.