Table 2.
Effects of AMG on caspase-3, Bax and Bcl-2 level in PPA-treated autistic rats.
| Groups | Caspase-3 (ng/mL) |
Bax (ng/mg Protein) |
Bcl-2 (ng/mg Protein) |
|---|---|---|---|
| Vehicle Control | 100.32 ± 0.52 | 4.80 ± 0.25 | 28.19 ± 0.25 |
| Sham Control | 100.85 ± 0.54 | 4.80 ± 0.25 | 28.21 ± 0.26 |
| AMG200 per se | 100.50 ± 0.52 | 4.80 ± 0.25 | 28.20 ± 0.26 |
| PPA | 150.93 ± 0.91 * | 10.73 ± 0.25 * | 18.67 ± 0.56 * |
| PPA + AMG100 | 140.92 ± 0.56 @ | 8.70 ± 0.23 @ | 21.16 ± 0.58 @ |
| PPA + AMG200 | 130.48 ± 0.55 @# | 6.92 ± 0.25 @# | 23.67 ± 0.24 @# |
Statistical analysis followed by one-way ANOVA (post-hoc Tukey’s test), * p < 0.05 v/s vehicle control; sham control and AMG200 per se; @ p < 0.05 v/s PPA; @# p < 0.05 v/s PPA + AMG100; (n = 6 rats per group).