Table 5.
Effects of AMG on the evaluation of oxidative stress markers in PPA-treated autistic rats.
| Oxidative Stress Markers | ||||||
|---|---|---|---|---|---|---|
| Groups | AchE (µM/mg Protein) |
LDH (Unit/mg Protein) |
SOD (µM/mg Protein) |
MDA (nM/mg Protein) |
Nitrite (µM/mg Protein) |
GSH (µM/mg Protein) |
| Vehicle Control | 16.30 ± 0.72 | 103.41 ± 0.88 | 453.25 ± 0.56 | 28.69 ± 0.58 | 4.14 ± 0.43 | 31.45 ± 0.35 |
| Sham Control | 16.92 ± 0.72 | 104.50 ± 0.97 | 453.54 ± 0.59 | 28.91 ± 0.58 | 4.14 ± 0.36 | 30.65 ± 0.40 |
| AMG200 per se | 16.31 ± 0.79 | 103.89 ± 0.70 | 453.53 ± 0.34 | 28.92 ± 0.37 | 4.15 ± 0.35 | 31.01 ± 0.40 |
| PPA | 48.89 ± 0.85 * | 377.45 ± 0.79 * | 310.53 ± 0.61 * | 66.86 ± 0.55 * | 9.92 ± 0.25 * | 6.60 ± 0.37 * |
| PPA + AMG100 | 35.38 ± 0.62 @ | 282.72 ± 0.89 @ | 323.38 ± 0.54 @ | 60.71 ± 0.69 @ | 7.42 ± 0.36 @ | 11.67 ± 0.36 @ |
| PPA + AMG200 | 28.32 ± 0.59 @# | 257.21 ± 0.56 @# | 340.25 ± 0.57 @# | 53.25 ± 0.58 @# | 5.87 ± 0.24 @# | 18.84 ± 0.57 @# |
Statistical analysis followed by one-way ANOVA (post-hoc Tukey’s test), * p < 0.05 v/s vehicle control; sham control and AMG200 per se; @ p < 0.05 v/s PPA; @# p < 0.05 v/s PPA + AMG100; (n = 6 rats per group).