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NETosis in physiologic (A) and pathologic conditions or ageing (B). Interleukins (ILs), tumor necrosis factors (TNFs), and interferones (IFNs). (A) NETs extrusion is adequate to the defensive anti-microbial action, and NETs are then removed by macrophages; inflammatory factors drop down. (B) Basal or induced NETs extrusion is enhanced, and they are not efficiently removed by macrophages; inflammatory factors increase, leading to long-lasting inflammation.
