. 2021 Feb 25;12(3):342. doi: 10.3390/genes12030342

Table 1.

Phenotypes of Δhst3 Δhst4 mutants.

Category	Phenotype	Source
Sensitivity to genotoxic agents:	Campthotecin (CPT)	[13]
	Bleomycin (ionizing radiation)	[13]
	Ultraviolet radiation (UV)	[40]
	Methyl Methanesulfonate (MMS)	[41]
	Hydroxyurea (HU)	[41]
	Peroxide (H₂O₂)	[51]
Genotoxic stress markers:	Rad52-foci accumulation	[48]
	Ddc2-foci accumulation	[48]
	Spontaneous Rad53 phosphorylation	[52]
Genome stability:	Increased loss of heterozygosity	[54]
	Elevated recombination rates	[55]
	Gross chromosomal rearrangements
	Small insertions/deletions
	Elevated rates of nondisjunction events
Chromatin changes:	Derepression of subtelomeric genes	[56]
Chromatin changes:	Sister chromatid cohesion defects	[48]
Other:	G₂/M cycle arrest/delay	[40]
Other:	Thermosensitivity	[40]