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. Author manuscript; available in PMC: 2022 Jan 4.
Published in final edited form as: Adv Biol (Weinh). 2021 Jan 4;5(1):e2000176. doi: 10.1002/adbi.202000176

Figure 4. In Vivo Skin Penetration Ability of 30Kc19α Using NIR Fluorophore.

Figure 4.

(A) ZW800–1C-30Kc19α conjugate was prepared and applied to the dorsal skin of hairless mice. Images were obtained with the fluorescence-assisted resection and exploration (FLARE) imaging system. (B) Magnified images after washing showed that the ZW800–1C-30Kc19α could penetrate the SC effectively. (C) The fluorescent signal was quantified based on the magnified images, and the normalized signal-to-background ratio (SBR) in ZW800–1C-30Kc19α was significantly higher than that of ZW800–1C, suggesting that 30Kc19α improves the skin penetration ability of small molecules (n=3) (***p<0.001).