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CD39 and CD73 are predominantly expressed in the activated stroma of HGSC. (A) Coimmunofluorescence analysis of αSMA, CD39 and CD73 protein expression in a cohort of 200 HGSC on tissue microarray (median, 95% CIs and Mann-Whitney U test p values are shown). (B) Representative staining of a tumor (Pt a) with coexpression of CD39 and CD73 in activated (αSMA+) stroma, and a tumor (Pt B) with high CD73 expression in tumor cells. HGSC, high-grade serous ovarian cancer.
