Table 3.
Median effect concentration (EC50) for zebrafish embryos/larvae exposed during 96 h to simvastatin (SIM) single versus combined with nanoplastics (NPls).
| Endpoints | EC50 (µg/L) | ||
|---|---|---|---|
| SIM | SIM + 0.015 NPls | SIM + 1.5 NPls | |
| Survival | 15.39 ± 0.36 | 15.33 ± 25.07 | 6.93 ± 5.60 |
| Malformations | 9.71 ± 1.44 | 9.79 ± 2.09 | n.d. |
| Hatching | 13.96 ± 0.33 | 15.05 ± 8.86 | n.d. |
| Heartbeat | 19.71 ± 2.15 | 27.29 ± 7.13 | n.d. |
Results are presented as estimated value ± standard error. SIM + 0.015 NPls: 12.5 or 15 µg/L SIM + 0.015 mg/L NPls; SIM + 1.5 NPls: 12.5 or 15 µg/L SIM + 1.5 mg/L NPls; n.d.: Not determined. (The exposure condition induced 100% mortality, which did not allow to evaluate the other endpoints: malformations, hatching and heartbeat).