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. 2021 Feb 26;11(3):186. doi: 10.3390/life11030186

Figure 1.

Figure 1

Comparison between de novo DNA methylation and maintenance DNA methylation. The figure compares de novo DNA methylation and maintenance DNA methylation. The two forms of DNA methylation catalyzed by DNMTs. (A) = unmethylated DNA; (B) = hemimethylated DNA; (C) and (D) = fully methylated DNA; DNMT3a/DNMT3b = DNA methyltransferases 3a/3b, both catalyze de novo DNA methylation (methylation of a newly formed double-stranded DNA during gametogenesis and embryogenesis). DNMT1 = DNA methyltransferase 1: It catalyzes replication-dependent maintenance of DNA methylation existing on hemimethylated DNA. Red dots stand for methyl groups. Source: Icons were obtained and customized in BioRender (biorender.com (accessed on 23 February 2021)).