Figure 4.

Cartoon representation of the zinc finger (ZF) array. A customized sequential array of six Cys2His2 ZFs: each of the six units containing a red dot surrounded by a coiled strand and two antiparallel arrows represent a Cys2His2 ZF. The red dot is the zinc ion coordinated by the side chains of two cysteines and two histidine residues. ZF arrays are employed in synthetic epigenetics to edit (add or delete) epigenetic marks at predetermined DNA or histone regions. They are usually coupled with writers or erasers to achieve this purpose. Source: Icons were obtained and customized in BioRender (biorender.com (accessed on 23 February 2021)).