Table 1.
Summary of zinc-binding domains and their functions.
| ZBD | Function | Example(s) | References |
|---|---|---|---|
| ADD | Allosteric control of the catalytic domain | DNMT3a/3b/3L | [31,41,57] |
| BTB/POZ | Readers of fully methylated DNA (double methylated CpG islands) | Kaiso (ZBTB33), ZBTB4, ZBTB38. | [10,117] |
| CXXC | Substrate recognition and self-regulation | DNMT1. | [49,50] |
| JmjC | H3K36me2 demethylation | KDM2B | [82] |
| KRAB | Reads fully methylated DNA (double methylated CpG islands) | ZFP57 | [10] |
| MYST | HAT activity (H3K9/K14 acetylation) | MOZ, MORF | [94] |
| PHD | Reads a broad range of histone marks and has E3-ubiquitin ligase activity. | UHRF1, UHRF2, BPTF | [11,40] |
| RING | E3-ubiquitin ligase | RNF168, PRC1, RNF20-RNF40 complex | [41] |
| SET | H3K4 methyltransferase activity | SET1A, SET1B | [45,76] |
| SRA | Reads hemimethylated DNA. | UHRF1, UHRF2. | [121,122] |