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Increased glycolytic activity of CRPC is measured in real-time using HP [1-13C]pyruvate. (A) Representative dynamic spectra of hyperpolarized [1-13C] pyruvate being converted to [1-13C] lactate in PC-3 cells. (B) summed HP 13C spectra show the lactate signal that arises from [1-13C]pyruvate. (C) Mean HP (Lac/Pyr) area under the curve (AUC) (* p < 0.05, n = 4).
