Table 1.
Subject characteristics.
| CF | Control | |
|---|---|---|
| Total | 101 | 51 |
| Female (%) | 47(46%) | 16(31%) |
| Mean age in years at time of bronchoscopy (±SD) | 3.6 (± 1.8) | 6.1 (±4.3) (p < 0.001) |
| Mean (±SD) total BAL cell count | 13.8 (± 25.9) × 106/L | 6.3 (±16.4) × 106/L (p = 0.02) |
| Mean (±SD) absolute neutrophil count | 4.8 (± 11.0) × 106 /L | 1.3 (± 3.3) × 106/L (p = 0.001) |
| Mean (±SD) IL-8 (pg/mL) | 507 (± 297) | 249 (± 243) (p < 0.001) |
| Mean Ln NE (ng/mL) | 4.1 (± 1.5) | 4.2 (± 0.9) (p = 0.55) |
| Genotype | Not applicable | |
| F508del homozygous | 58 (57%) | |
| F508del heterozygous | 22 (22%) | |
| Other | 9 (9%) | |
| No data | 12(12%) | |
| BAL culture results (total #) | (n = 273) | (n = 51) |
| P. aeruginosa (% of total) | 12 (4.4%) | 1 (1.9%) |
| S. aureus (% of total) | 55 (20.1%) | 3 (5.8%) |
| H. influenzae (% of total) | 67 (24.5%) | 14 (27.4%) |
| S. pneumoniae (% of total) | 24 (8.8%) | 8 (15.7%) |
| M. catarrhalis (% of total) | 8 (2.9%) | 4 (7.8%) |
| S. maltophilia (% of total) | 11 (4.0%) | 1 (1.9%) |
| Pancreatic insufficient | 81 of 83 with data 98% | Not applicable |
| Mean (±SD) weight z-score at time of bronchoscopy | −0.01 (±1.6) | No data |
| Mean (±SD) height z-score at time of bronchoscopy | −0.16 (± 2.1) | No data |
Definition of abbreviations: SD = standard deviation, BAL = bronchoalveolar lavage, Ln = natural log, and NE = neutrophil elastase. # number.