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SMA patients with or without CSF–blood barrier dysfunction according to age-adjusted reference levels for QAlbumin throughout therapy (d0 to m22). CSF: cerebrospinal fluid; d: day; m: month; SMA: spinal muscular atrophy.
| Time Point | n | CSF–Blood Barrier Dysfunction | |
|---|---|---|---|
| Yes | No | ||
| d0 | 24 | 6 (25%) | 18 |
| d14 | 19 | 3 (15.8%) | 16 |
| d28 | 14 | 1 (7.1%) | 13 |
| d63 | 22 | 7 (31.8%) | 15 |
| m6 | 18 | 7 (38.9%) | 11 |
| m10 | 17 | 5 (29.4%) | 12 |
| m14 | 13 | 3 (23.1%) | 10 |
| m18 | 6 | 2 (33.3%) | 4 |
| m22 | 2 | 0 | 2 |
