Figure 1.

Overview of chemical structures of the neutral and acidic glycosphingolipid (GSL) subclasses studied in this work: (A) General structure of neutral GSL depicting individual parts of the complex molecule with possible modifications of N-linked fatty acyl chain (dashed boxes). (B) Basic structures of GSL subclasses using the established glycan symbols (the letter and the number within symbols define the nature of the glycosidic linkage). Abbreviations used in the figure are as follows: ceramides (Cer), N-acetylneuraminic acid (Neu5Ac), galactose (Gal), glucose (Glc), N-acetylgalactosamine (GalNAc), globotetraosylceramides (Gb₄), globotriaosylceramides (Gb₃), dihexosylceramide (Hex₂Cer), monohexosylceramide (HexCer)—glucosylceramide (GlcCer) or galactosylceramide (GalCer), monohexosylsulfatide (SHexCer), dihexosylsulfatide (SHex₂Cer), monosialodihexosylganglioside (GM₃).