Table 2.
Design of experiments using the Box–Behnken method to optimize the NioC.
| Run | Levels of Independent Variables | Dependent Variables | ||||
|---|---|---|---|---|---|---|
| A(mg) | B (Molar Ratio) | C (Molar Ratio) | Average Size (nm) | Entrapment Efficiency (EE) (%) | Release (pH 7.4) (%) | |
| 1 | 1 | 0 | −1 | 172.2 | 96.57 | 69.25 |
| 2 | −1 | 1 | 0 | 223.9 | 90.21 | 47.85 |
| 3 | 0 | 0 | 0 | 191.3 | 95.6 | 61.47 |
| 4 | 1 | −1 | 0 | 322.1 | 89.85 | 55.90 |
| 5 | 0 | 1 | −1 | 198.7 | 84.51 | 51.50 |
| 6 | 0 | 0 | 0 | 187.3 | 96.03 | 64.75 |
| 7 | −1 | −1 | 0 | 305.6 | 87.36 | 43.29 |
| 8 | −1 | 0 | −1 | 163.4 | 86.54 | 50.67 |
| 9 | −1 | 0 | 1 | 208.5 | 94.1 | 61.07 |
| 10 | 0 | −1 | −1 | 269.1 | 80.29 | 53.22 |
| 11 | 1 | 0 | 1 | 280.6 | 97.49 | 66.39 |
| 12 | 0 | 0 | 0 | 186.7 | 95.82 | 62.50 |
| 13 | 1 | 1 | 0 | 244.6 | 90.85 | 58.33 |
| 14 | 0 | 1 | 1 | 295.7 | 93.75 | 60.11 |
| 15 | 0 | −1 | 1 | 358.4 | 92.12 | 60.85 |