Table 4.
Variance analysis of the quadratic polynomial model for size 1.
| Source | Sum of Squares | Degree of Freedom | Mean Square | F-Value | p-Value | Evaluation |
|---|---|---|---|---|---|---|
| Model | 51617.35 | 9 | 5735.26 | 60.90 | 0.0001 | Significant |
| A | 1743.45 | 1 | 1743.45 | 18.51 | 0.0077 | |
| B | 10,679.91 | 1 | 10,679.91 | 113.41 | 0.0001 | |
| C | 14,433.00 | 1 | 14,433.00 | 153.27 | <0.0001 | |
| AB | 4.41 | 1 | 4.41 | 0.047 | 0.8372 | |
| AC | 1001.72 | 1 | 1001.72 | 10.64 | 0.0224 | |
| BC | 14.82 | 1 | 14.82 | 0.16 | 0.7079 | |
| A2 | 118.22 | 1 | 118.22 | 1.26 | 0.3134 | |
| B2 | 23,606.16 | 1 | 23,606.16 | 250.68 | <0.0001 | |
| C2 | 539.10 | 1 | 539.10 | 5.72 | 0.0622 | |
| Residual | 470.85 | 5 | 94.17 |
1 Particle Size = + 188.43 + 14.76 * A − 36.54 * B + 42.48 * C + 1.05 * A * B + 15.83 * A * C + 1.93 * B * C + 5.66 * A2 + 79.96 * B2 + 12.08 * C2; where A is drug content, B is surfactant: cholesterol, and C is lipid: drug, according to the normalized data between −1 and 1.