Table 5.
Variance analysis of the quadratic polynomial model for EE 1.
| Source | Sum of Squares | Degree of Freedom | Mean Square | F-Value | p-Value | Evaluation |
|---|---|---|---|---|---|---|
| Model | 317.09 | 9 | 317.09 | 5.24 | 0.0415 | Significant |
| A | 34.24 | 1 | 34.24 | 5.39 | 0.0397 | |
| B | 11.76 | 1 | 11.76 | 1.75 | 0.2434 | |
| C | 109.15 | 1 | 109.15 | 16.22 | 0.0100 | |
| AB | 0.86 | 1 | 0.86 | 0.13 | 0.7359 | |
| AC | 11.02 | 1 | 11.02 | 1.64 | 0.2567 | |
| BC | 1.68 | 1 | 1.68 | 0.25 | 0.6388 | |
| A2 | 0.054 | 1 | 0.054 | 8.012 × 10−3 | 0.9321 | |
| B2 | 138.67 | 1 | 138.67 | 20.61 | 0.0062 | |
| C2 | 15.08 | 1 | 15.08 | 2.24 | 0.1946 | |
| Residual | 33.64 | 5 | 33.64 |
1 EE = + 95.82 + 2.07 * A + 2.21 * B + 3.69 * C − 0.46 * A * B − 1.66 * A * C − 0.65 * B * C − 0.12 * A2 − 6.13 * B2 − 2.02 * C2; where A is drug content, B is surfactant: cholesterol, and C is lipid: drug, according to the normalized data between −1 and 1.