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The optimized responses were attained by the Box–Behnken method and the empirical data for the similar reactions under optimum status.
| Parameter | Predicted by RSM | Experimental Data |
|---|---|---|
| Average size (nm) | 167.1 | 177.53 ± 4.53 |
| Entrapment Efficiency (EE) (%) | 94.949 | 96.34 ± 1.67 |
| Release (%) | 67.12 | 61.7 ± 1.23 |
