Table 1. Summary of dropout patients with reasons at different stages of study.

Study stage	Reasons of drop-out	N (%)
Initial screening or Pre-assessment	Used homeopathic or herbal medications	95 (4.65)
	Performed cupping therapy	57 (2.79)
	Pregnant women	20 (0.97)
	Used multiple anti-migraine drugs	59 (2.88)
	Used other class of anti-migraine drugs	101 (4.94)
	Not provide complete data of drug regimen	22 (1.07)
During or end of study	Died or moved away	41 (2.00)
	Pregnancy	5 (0.24)
	Follow-up period of less than 12 months and not experienced any event during this period	46 (2.25)

Total participants enrolled initially = 2043 N

Total drop out patients = 446 N (21.8%)

Data of patients who drop-out during the study period due to any above defined reasons were censored in survival analysis