Fig 3. An example interacting TF-SNP-Gene triplet.

(A) TF MAX binds to MTOR promoter region supported by DNase, H3K4me3, H3K27ac and MAX CHIP-Seq independently across several cell lines from ENCODE (K562, GM12878, and A549), and the binding is predicted to be specific to ‘G’ allele. (B) MAX gene is age-associated. (C)-(E) The correlations between adjusted MAX and MTOR expression across the three genotypes.