Fig 1. Pedigree of the South African family ZA253.

For readability and confidentiality, the pedigree is greatly simplified. Circles denote females and squares depict males. The filled in symbols indicate affected individuals. The diagonal line indicates that the person is deceased, and the arrow indicates the proband. The numbers below each individual is the laboratory ID number and age at onset of disease. Branches without clinically confirmed PD or without DNA samples were omitted, but all known living family members with PD diagnoses are included.