Fig. 1.

aiLUNG simulations of the effect of LOF and GOF mutations in the SARS-CoV-2 genome on viral infectivity. A, LOF simulations and their virulence estimation. Red bars represent mutations in SARS-CoV2 that result in a significant decrease in infectivity. B, GOF simulations their infectivity estimation. Red bars represent mutations in SARS-CoV2 that result in a significant increase in infectivity. A, B, Green bar represents aiLUNG-WT; Yellow bar represents aiLUNG-COVID-19 (unmutated original SARS-CoV2 genome) simulations; blue bars represent mutations that has no significant effect on infectivity. These data represent the average from 3 experiments ± the 95% confidence interval around the average. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)