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. 2021 Mar 26;19:1701–1712. doi: 10.1016/j.csbj.2021.03.020

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Heat map representation of summary DeepNEU simulations data of the effects of individual LOF mutations. A, effect of LOF on the SARS-CoV-2 genome and B, effect of LOF on phenotypic profile of simulated ATI and ATII cells. Data are the average of 3 separate experiments. Data represented as dnCFR measure +/- the 95% CI around the estimates is presented. dnCFR is the DeepNEU measure of SAR-CoV-2 infectivity, where (-4) represents the maximum reduction in viral infectivity and (+4) represents the maximum increase in infectivity.