Table 2. QUADAS-2 assessment of eligible studies.

Author, year	Risk of bias				Applicability concerns
	Patient selection	Index test	Reference standard	Flow and timing		Patient selection	Index test	Reference standard
Bidard et al, 2019 [48]	low	low	low	unclear		low	low	low
Sclafani et al, 2018 [49]	low	unclear	low	high		low	low	low
Kang et al, 2020 [13]	low	unclear	unclear	high		low	low	low
Kato et al, 2019 [19]	low	unclear	unclear	high		low	low	low
Chang et al, 2018 [29]	unclear	high	low	unclear		low	low	low
Garcia et al, 2018 [30]	low	low	low	low		low	low	low
Wang et al, 2017 [31]	unclear	unclear	low	unclear		low	low	low
Kidess-Sigal et al, 2016 [50]	low	unclear	unclear	unclear		low	low	low
Kim et al, 2015 [32]	low	unclear	low	unclear		low	low	low
Vessies et al, 2020 [33]	low	unclear	low	high		low	low	low
Cao et al, 2020 [34]	low	unclear	unclear	unclear		low	low	low
Gupta et al, 2020 [35]	low	low	low	unclear		low	low	low
Kitagawa et al, 2019 [14]	unclear	unclear	unclear	unclear		low	low	low
Galbiati et al, 2019 [51]	low	unclear	low	unclear		low	low	low
Choi et al, 2019 [36]	low	low	low	unclear		low	low	low
Liebs, et al, 2019 [18]	unclear	unclear	unclear	unclear		low	low	low
Osumi et al, 2019 [37]	low	unclear	unclear	unclear		low	low	low
Galbiati et al, 2019 [52]	unclear	unclear	low	low		low	low	low
Takayama et al, 2018 [53]	unclear	unclear	low	unclear		low	low	low
Yao et al, 2018 [38]	low	unclear	low	low		low	low	low
Sun et al, 2018 [39]	low	low	low	low		low	low	low
Normanno et al, 2018 [40]	low	unclear	unclear	unclear		low	low	low
García-Foncillas et al, 2018 [41]	unclear	unclear	low	unclear		low	low	low
Beije et al, 2016 [42]	low	low	low	low		low	low	low
Sefrioui et al, 2017 [54]	low	unclear	low	high		low	low	low
Grasselli et al, 2017 [43]	low	low	low	unclear		low	low	low
Schmiegel et al, 2017 [44]	low	unclear	unclear	low		low	low	low
Vidal et al, 2017 [45]	low	unclear	low	unclear		low	low	low
Beranek et al, 2016 [47]	unclear	unclear	unclear	unclear		low	low	low
Rachiglio et al, 2016 [46]	low	unclear	unclear	low		low	low	low
Yamada et al, 2016 [55]	low	low	low	low		low	low	low
Spindler et al, 2015 [20]	low	unclear	unclear	unclear		low	low	low
Taly et al, 2013 [12]	unclear	unclear	unclear	unclear		low	low	low