Table 3. Classification Performance of the Consensus Approaches Estimated on the Binding, Antagonism, and Agonism Sets Considering the Best Five Models Only (Selected Based on NER)a.
| binding (5 models) |
antagonism (5 models) |
agonism (5 models) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| consensus approach | Sn (%) | Sp (%) | NER (%) | Cvg (%) | rank | Sn (%) | Sp (%) | NER (%) | Cvg (%) | rank | Sn (%) | Sp (%) | NER (%) | Cvg (%) | rank |
| MVL | 63.9 | 97.7 | 80.8 | 92.8 | 3 | 71.6 | 82.8 | 77.2 | 96.5 | 2 | 73.8 | 98.8 | 86.3 | 98.6 | 2 |
| MVI | 65.7 | 99.3 | 82.5 | 88.4 | 4 | 71.9 | 84.4 | 78.1 | 90.9 | 3 | 74.1 | 99.0 | 86.5 | 97.0 | 4 |
| MVS | 63.8 | 99.5 | 81.6 | 87.4 | 6 | 78.3 | 87.6 | 83.0 | 74.4 | 5 | 73.1 | 99.2 | 86.1 | 95.8 | 6 |
| B | 72.0 | 91.0 | 81.5 | 100 | 1 | 73.2 | 79.7 | 76.5 | 100 | 1 | 74.4 | 96.1 | 85.2 | 99.9 | 3 |
| Bp | 88.3 | 96.2 | 92.2 | 58.6 | 7 | 79.4 | 85.5 | 82.4 | 76.3 | 4 | 76.1 | 98.2 | 87.1 | 90.0 | 7 |
a
For each consensus approach, sensitivity (Sn), specificity (Sp), non-error rate (NER), coverage (Cvg), and total ranking are reported. B, Bayes; Bp, protective Bayes; MVL, majority voting loose; MVI, majority voting intermediate; MVS, majority voting strict.