Table 1.
Apparent permeabilities (Papp) of microcystin-RR, following exposure of Caco-2 cell monolayers. Transport experiments were performed from apical to basolateral compartments (A–B) and from basolateral to apical compartments (B–A). Papp values are presented as mean ± SEM and expressed in 10−8 cm·s−1. Four independent experiments were performed. Not determined (ND); not applicable (NA).
| Transport | Loaded Concentration (µM) | Time (h) | ||||
|---|---|---|---|---|---|---|
| 1 | 2 | 4 | 6 | 24 | ||
| A–B | 1 | NA | NA | NA | NA | NA |
| 10 | NA | NA | NA | NA | 10.0 ± 5.2 | |
| 25 | NA | NA | 14.8 ± 1.8 | 14.3 ± 5.7 | 7.9 ± 4.2 | |
| 55 | NA | NA | 4.0 ± 2.4 | 8.7 ± 4.2 | 10.8 ± 5.6 | |
| B–A | 1 | NA | NA | NA | 37.0 ± 10.7 | ND |
| 10 | NA | NA | NA | 11.5 ± 5.3 | ND | |
| 25 | NA | 5.8 ± 3.8 | 2.2 ± 0.6 | 5.9 ± 1.0 | ND | |
| 55 | NA | 3.2 ± 1.0 | 3.1 ± 0.8 | 9.9 ± 5.2 | ND | |