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. 2021 Feb 28;9(3):202. doi: 10.3390/vaccines9030202

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effect of CMV serostatus on aged T/B cell subsets and immunogenicity of the HZ vaccine. (a) The frequencies of CD4+CD28−, CD8+CD28−, and ABCs before vaccination. (b) Levels of anti-glycoprotein (gp) VZV IgG antibody before and after vaccination. GMFR after vaccination over before vaccination is shown under the figure. (c) The number of VZV stimulated IFN-γ secreting T cell spots before and after vaccination. HZ, herpes zoster; gp, glycoprotein; VZV, varicella zoster virus; GMFR, geometric mean fold rise; ABCs, age associated B cells; cytomegalovirus, CMV. Patients were divided into subgroups according to their CMV serostatus.