Table 1.
Clinical characteristics of the study cohort.
| Population Characteristics | Normal Weight (n = 26) |
Overweight (n = 22) |
p-Value | Obese (n = 20) |
p-Value |
|---|---|---|---|---|---|
| Age (years) | 24 (23–27) | 24 (23–29) | 0.976 | 26 (22–32) | 0.373 |
| BMI (kg/m2) | 21.8 (20.5–23.3) | 27.0 (26.3–27.4) | <0.001 | 33.0 (31.4–35.3) | <0.001 |
| DINCL (mm) | 83.6 (66.1–99.1) | 140.8 (120.2–162.0) | <0.001 | 196.9 (189.7–223.7) | <0.001 |
| HDL-cholesterol (mg/dL) | 80.0 (67.0–86.5) | 75.0 (61.2–81.8) | 0.239 | 58.0 (48.8–68.0) | <0.001 |
| LDL-cholesterol (mg/dL) | 80.0 (64.5–101.5) | 82.0 (65.5–105.0) | 0.740 | 106.5 (79.2–120.8) | 0.031 |
| VLDL (mg/dL) | 21.0 (16.5–24.0) | 22.5 (19.0–25.5) | 0.309 | 27.5 (24.0–33.5) | <0.001 |
| Triglycerides (mg/dL) | 66.0 (50.0–88.0) | 78.5 (65.5–122.8) | 0.057 | 105.0 (79.2–143.5) | 0.005 |
| HbA1c (mmol/mol) | 31.0 (30.0–32.5) | 33.0 (31.0–33.0) | 0.069 | 34.0 (32.0–36.5) | <0.001 |
| CRP (mg/L) | 1.3 (0.6–2.4) | 1.4 (0.8–3.5) | 0.345 | 5.3 (3.0–8.2) | <0.001 |
| IL-6 (pg/mL) | 1.5 (1.5–2.1) | 2.0 (1.5–2.5) | 0.119 | 3.6 (2.8–4.5) | <0.001 |
| Leptin (ng/mL) | 10.9 (7.8–14.9) | 23.9 (19.1–39.2) | <0.001 | 49.1 (37.1–50.0) | <0.001 |
| sOB-R (ng/mL) | 19.5 (16.4–21.5) | 15.1 (12.4–18.0) | 0.003 | 10.2 (9.3–12.2) | <0.001 |
| Adiponectin (µg/mL) | 11.7 (9.4–15.5) | 10.8 (9.4–12.1) | 0.287 | 8.4 (7.0–10.5) | 0.018 |
| ALP (U/L) | 50.0 (43.0–54.5) | 51.0 (47.5–64.0) | 0.136 | 60.5 (55.0–80.0) | <0.001 |
| GGT (U/L) | 12.0 (10.5–16.0) | 13.0 (11.0–16.8) | 0.408 | 17.0 (15.8–23.0) | 0.002 |
| CHE (U/L) | 7225.0 (6604.0–7872.5) | 7378.5 (6219.5–8535.0) | 0.695 | 8253.5 (7682.8–9609.8) | <0.001 |
| ALT (U/L) | 14.0 (12.0–19.5) | 18.0 (13.0–21.8) | 0.197 | 23.0 (19.0–26.0) | <0.001 |
Clinical characteristics of the study cohort. Data are presented as median (Q1–Q3). Differences between normal weight women and either overweight or obese women were assessed by Wilcoxon rank sum test. n, number of subjects; BMI, body mass index; DINCL, thickness of subcutaneous adipose tissue at eight measured body sites; HDL, high-density lipoprotein; LDL, low-density lipoprotein; HbA1c, glycated hemoglobin A1c; CRP, C-reactive protein; IL-6, interleukin-6; sOB-R, soluble leptin receptor; ALP, alkaline phosphatase; GGT, gamma-glutamyl transpeptidase; CHE, cholinesterase; ALT, alanine transaminase.