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. Author manuscript; available in PMC: 2021 Mar 26.
Published in final edited form as: ACS Appl Mater Interfaces. 2020 Mar 2;12(10):11307–11319. doi: 10.1021/acsami.9b20071

Scheme 1.

Scheme 1.

Schematic Illustration of (a) TK–p53–NTR Triple-Gene-Loaded PLGA–PEG–PEI NP Surface Functionalized with SP94; (b) Targeted Delivery and Order of Events Occur upon the Cellular Uptake of Nanoparticle and Prodrugs in HCC cells, and (c) Subsequent Intracellular Gene Expression and Signaling Cascades Activate Apoptosis in HCC Cells