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The influence of rapamycin pre-treatment (3 and 10 mg/kg, i.p.) during ethanol administration (PND 4-9) on anxiety-like behavior (PND 59) and locomotor activity (PND 60) in adult male and female rats measured in the elevated plus maze (EPM). (A) Percent of time in the open arms of the EPM apparatus; (B) percent of open arm entries in the EPM apparatus; (C) locomotion measured in the locomotor activity boxes. Results are expressed as mean ± S.E.M. of 8 subjects per group.
