Table 2.
Acrylamide intake and the risk of renal cell cancer.
| Tertile1 | Tertile2 | Tertile3 | p for Trend | ||||
|---|---|---|---|---|---|---|---|
| HRs | 95% CI | HRs | 95% CI | ||||
| Number of participant | 29,606 | 29,606 | 29,606 | ||||
| Cases (n = 208), n | 81 | 66 | 61 | ||||
| Person-years (n = 1,346,982), n | 447,582 | 451,430 | 447,970 | ||||
| Model 1 adjusted HRs (95% CI) | Reference | 0.90 | (0.65–1.25) | 0.89 | (0.63–1.24) | 0.471 | |
| Model 2 adjusted HRs (95% CI) | Reference | 0.83 | (0.45–1.53) | 0.71 | (0.38–1.34) | 0.294 | |
| Model 3 adjusted HRs (95% CI) | Reference | 0.82 | (0.43–1.59) | 0.67 | (0.34–1.32) | 0.25 | |
| Current or past smoker | |||||||
| Cases (n = 88), n | 29 | 30 | 29 | ||||
| Person-years (n = 407,260), n | 135,171 | 126,646 | 145,443 | ||||
| Model 1 adjusted HRs (95% CI) | Reference | 1.16 | (0.69–1.93) | 1.00 | (0.59–1.69) | 0.990 | |
| Model 2 adjusted HRs (95% CI) | Reference | 0.81 | (0.42–1.59) | 0.85 | (0.44–1.65) | 0.990 | |
| Model 3 adjusted HRs (95% CI) | Reference | 0.83 | (0.41–1.68) | 0.79 | (0.39–1.60) | 0.513 | |
| Never smoker | |||||||
| Cases (n = 110), n | 46 | 33 | 31 | ||||
| Person-years (n = 866,655), n | 286,730 | 301,249 | 278,676 | ||||
| Model 1 adjusted HRs (95% CI) | Reference | 0.78 | (0.50–1.23) | 0.90 | (0.56–1.44) | 0.592 | |
| Model 2 adjusted HRs (95% CI) | Reference | 0.81 | (0.51–1.27) | 0.93 | (0.58–1.50) | 0.711 | |
| Model 3 adjusted HRs (95% CI) | Reference | 0.77 | (0.47–1.25) | 0.96 | (0.58–1.58) | 0.784 | |
HRs: hazard ratios; CI: confidence interval; Model 1: adjusted for age, sex, and public health center area; Model 2: additionally adjusted for body mass index, smoking status (never, past, current, missing), number of cigarettes per day (only for current), physical activity (METs), history of hypertension, energy intake, intake of alcohol, vegetable consumption, fruit consumption, and meat consumption; Model 3: model 2, excluding cases diagnosed under three years.