Fig. 1.

Structure of the SARS-CoV-2 M^pro-boceprevir and M^pro-telaprevir bound complexes. The crystal structures of SARS-CoV-2 M^pro in complex with (A) boceprevir and (B) telaprevir are shown. The M^pro is shown in a green cartoon, and the residues within 4 Å of boceprevir (cyan stick) and telaprevir (cyan stick) are shown as stick models and labeled. Interacting hydrogen bonds are shown as yellow dashes. In (C) and (D), various types of intermolecular interactions between boceprevir and telaprevir with M^pro are shown and specified in the legend, respectively. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)