Fig. 3.
Heatmaps showing the mutations and their frequencies at the boceprevir and telaprevir binding sites of Mproretrieved from GISAID and CoV-GLUE databases. Mutations at the boceprevir and telaprevir binding site of SARS-CoV-2 Mpro obtained from GISAID and CoV-GLUE databases are shown, where the frequencies of the mutations among the COVID-19 infected cases ranged from lower to higher numbers are denoted from red to green colors respectively. The computed mutants that developed tolerance and adaptation towards boceprevir and telaprevir are denoted as ’B’ and ‘T’ respectively adjacent to the mutants. It was found that out of 64 mutations, 42 mutations were predicted as tolerant and positively selected from our design calculations, thus achieving ∼65% correlation and match with the sequencing data. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)