Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 27;13(3):773. doi: 10.3390/nu13030773

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Rosemary extract (RE) protected against loss of barrier integrity in DSS-induced colitis mice. FITC–dextran was administered and analyzed in mouse plasma according to Section 2.12 (n = 7 samples per group). (A) DSS administration significantly increased plasma levels of FITC, indicating severe loss of intestinal barrier integrity. RE at 100 mg/kg protected intestinal barrier disruption as shown by decreased plasma FITC compared to negative control. (B) Zonula occludens-1 (ZO-1) protein expression from mouse colon lysates was analyzed by Western blot. RE administration at both 10 and 100 mg/kg significantly increased ZO-1 protein expression. (C) Western blot images of ZO-1 protein expression in mouse colon lysates representative of each group from the DSS colitis experiment. One-way ANOVA followed by Tukey’s HSD was used to determine significance. * p < 0.05.