Table 2.

Fasting Blood Glucose Based Dosage Titration Protocol

Fasting Capillary Glucose (mmol/L)	Glargine Dose Adjustment (U)a
≤2.8	−6 (if total dose > 45 U, reduce 15%), contact the investigator as a emergency problems
2.9–3.8	−4 (if total dose > 45 U, reduce 10%)
3.9–4.3	−2 (if total dose > 45 U, reduce 5%)
4.4–6.1	0
6.2–7.8	+2
7.9–9.9	+4
≥10	+6

Notes: ^aDose should be adjusted every 3–4 days to achieve a target range for fasting capillary glucose of 4.4–6.1mmol/L. Change in insulin dose were based on the median of fasting capillary glucose values measured on 3 consecutive days of which the last is the day when titration is to occur.