Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 27;14(3):198. doi: 10.3390/ph14030198

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Inactivation of CYP3A4 (A,B) and CYP3A5(C) activity by STA. Various concentrations of STA (0, 0.25, 0.5, 1, 2 μM) and NADPH (Nicotinamide Adenine Dinucleotide Phosphate) at were preincubated at 37 °C for 0, 5, 10, 20 and 30 min in 0.1 M phosphate buffer solution (PBS). (A,C) a plot of the log of percentage of control activity versus pre-incubation time. (B) a plot of the half-life of enzyme inactivation versus the inverse of the STA concentration. Each point represents the average of triplicate experiments (mean and SD values are listed in Table S1).