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Inactivation of CYP3A4 (A,B) and CYP3A5 (C,D) activity by SIA. Various concentrations of SIA (0, 2, 4, 8, 16 μM) and NADPH at were preincubated at 37 °C for 0, 5, 10, 20 and 30 min in 0.1M PBS). (A,C) a plot of the log of percentage of control activity versus pre-incubation time. (B,D) a plot of the half-life of enzyme inactivation versus the inverse of the SIA concentration. Each point represents the mean of triplicate experiments (mean and SD values are listed in Table S1).
