Table 1.

Simulation results of tacrolimus with different doses.

Parameters		Cmax (ng/mL)			Tmax (h)			AUC (ng/mL·h)
Dose	Population	Pre 3	Obs 4	FE 5	Pre	Obs	FE	Pre	Obs	FE
1 mg	Exp 1 (n = 16)	5.74	3.88	1.48	1.08	1.75	1.61	22.50	19.34	1.16
	Non-exp 2 (n = 26)	9.93	5.52	1.80	1.08	1.5	1.38	37.47	30.34	1.24
2 mg	Exp (n = 31)	14.50	14.09	1.03	1.08	1.26	1.16	71.53	60.83	1.18
	Non-exp (n = 40)	23.87	24.28	1.02	1.08	1.35	1.25	102.54	119.02	1.16
5 mg	Exp (n = 12)	21.41	20.8	1.03	0.84	1.40	1.67	131.07	90.40	1.45
	Non-exp (n = 12)	36.73	27.90	1.32	0.84	1.30	1.55	227.07	134.77	1.68

¹ Exp: CYP3A5 expressers; ² Non-exp: CYP3A5 non-expressers; ³ Pre: Predicted; ⁴ Obs: Observed; ⁵ FE: Fold error.