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. 2021 Feb 27;11(3):363. doi: 10.3390/biom11030363

Figure 4.

Figure 4

CTCF facilitates homologous recombination repair. During DSB repair, CTCF is recruited to DSBs in a PAR- or/and MRE11-dependent manner and, in turn, recruits CtIP. The MRE11–CtIP complex induces DNA end resection, followed by the loading of RPA onto the resultant single-strand DNA. CTCF also recruits BRCA2 to DSBs in a PARylation-dependent manner. CTCF and BRCA2, in turn, recruit RAD51, which forms filaments to allow strand invasion and homologous recombination to complete the DNA repair.