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Structure of the EV-A71 genome and the encoded viral proteins. The single open reading frame (ORF) is flanked by a highly structured 5′UTR and 3′UTR followed by a poly (A) tail. The 5′ end of the viral genome is covalently bound to the viral VPg protein. The ORF is divided into three regions. P1 encodes four structural (capsid) proteins, VP1–4. P2 and P3 encode seven nonstructural proteins, 2 A to 2 C and 3 A to 3 D, respectively [11].
