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. 2021 Mar 26;7(13):eabb8087. doi: 10.1126/sciadv.abb8087

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 1 — (A) Ifnar1^fl/fl;Mb1Cre, Ifnar1^fl/fl;CD4Cre, Ifnar1^fl/fl;CD11cCre, Ifnar1^fl/fl;NCR1Cre, and Ifnar1^fl/fl littermate control mice were infected with LCMV Cl13. Viral titers in serum were measured by focus-forming assay (FFU) at indicated time points. (B to E) Ifnar1^fl/fl;NCR1Cre and littermate control mice were infected with LCMV Cl13. Frequency and number of GP33- or GP276-specific CD8 T cells (B), GP33-specific cytokine-producing CD8 T cells (C), GP61-specific cytokine-producing CD4 T cells (D), and T_FH, GCB, and plasma cells (E) in the spleen were analyzed at day 6 after infection. Statistical comparisons were performed using two-way ANOVA followed by Mann-Whitney U test with Holm-Šídák multiple testing correction (A) or two-tailed Student’s t test (B to E).