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. 2021 Mar 26;7(13):eabf9180. doi: 10.1126/sciadv.abf9180

Fig. 5. In vivo activity of LRP1-targeted conjugates bearing BDMC or genistein in AβPP/PS1 Alzheimer’s murine model.

Fig. 5

(A and B) Aβ40 or Aβ42 levels determined in whole brain homogenates by enzyme-linked immunosorbent assay (ELISA). (C) Plasma leptin levels determined by the Quantikine ELISA Leptin Immunoassay Kit. (D) Hippocampal learning evaluated using the Hebb-Williams maze. (E) Recognition memory studied using the novel object recognition test. (F) Olfactory deficits assessed by the odor habituation test. Data are expressed as means ± SD. Significance is shown as *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, and ****P < 0.0001 versus TG, n = 5 to 10 animals per group.