Fig. 3. Tooth nociceptor cold responses are much larger than skin cold nociceptor responses.
(A) Schematic illustration of extracellular recordings from jaw-nerve as compared to skin-nerve preparations.(B to D) Comparison of the (B) cold response magnitude, (C) peak frequency, and (D) threshold temperature of C57BL/6J teeth (n = 45) and skin (n = 59) nociceptors. Statistical significance was identified by a two-sided Student’s t test: ***P = 2 × 10−8, ***P = 3 × 10−11, and *P = 0.05. Skin nociceptor cold responses are from (6, 50) and refer to the same background strain at equivalent stimulus conditions.