Table 2.
For each ion monitored, the average of the AUC was calculated in nonexposed and exposed oral-cell DNA and normalized by the ISs AUC and µmol of dG. The adducts that were only present after exposure are labelled as “+”, while those present in samples before and after exposure were labelled as “*”, when the levels increased significantly after exposure (p ≤ 0.05).
| [M + H]+ | Average Non-Exposed (AUC/µmol dG) | Average Exposed (AUC/µmol dG) | |
|---|---|---|---|
| 272.1240 | 30.8 | 2520 | * |
| 256.1292 (N4-ethyl-dC) |
2.66 | 392 | * |
| 280.1404 (N6-ethyl-dA) |
0.235 | 5.15 | * |
| 296.1353 (N2-ethyl-dG) |
43.2 | 6930 | * |
| 296.1353 | 1.15 | 93.5 | * |
| 298.1397 | 2.10 | 129 | |
| 306.1560 | - | - | |
| 313.1394 | - | 2.48 | + |
| 322.1509 | 40.8 | 1410 | * |
| 324.1666 | 0.0001 | 12.3 | |
| 326.1710 | - | - | |
| 338.1458 | - | 183 | + |
| 340.1615 | - | - | |
| 340.1615 | 0.561 | 32.7 | |
| 342.1659 | - | 47.4 | + |
| 366.1771 | 1.39 | 43.5 | * |
| 382.172 | 81.0 | 10,800 | * |
| 481.2041 | - | - | |
| 505.2153 | - | 1.06 | + |
| 521.2102 | - | 1.94 | + |
| 587.2320 | - | - | |
| 589.2477 | - | 0.533 | + |
* p ≤ 0.05, + only in exposed.