Table 3. Cytotoxic Activity of Newly Synthesized G4 Binders in Human U2OS and HeLa Cell Lines after 1 and 24 h of Treatment Followed by 48 h of Recovery in a Drug-Free Mediuma.
| IC50 (μM) |
||||
|---|---|---|---|---|
| U2OS cell line |
HeLa cell line |
|||
| 1 h of treatment | 24 h of treatment | 1 h of treatment | 24 h of treatment | |
| compound 1 | >100 | >50 | >100 | >50 |
| compound 15 | 12.51 ± 1.12 | 2.06 ± 1.23 | 3.94 ± 1.17 | 0.75 ± 1.19 |
Concentrations killing 50% of cells (IC50) are shown as the mean ± SE of two independent experiments performed in triplicate.