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. 2020 Mar 6;63(6):3090–3103. doi: 10.1021/acs.jmedchem.9b01866

Table 3. Cytotoxic Activity of Newly Synthesized G4 Binders in Human U2OS and HeLa Cell Lines after 1 and 24 h of Treatment Followed by 48 h of Recovery in a Drug-Free Mediuma.

  IC50 (μM)
  U2OS cell line
HeLa cell line
  1 h of treatment 24 h of treatment 1 h of treatment 24 h of treatment
compound 1 >100 >50 >100 >50
compound 15 12.51 ± 1.12 2.06 ± 1.23 3.94 ± 1.17 0.75 ± 1.19
a

Concentrations killing 50% of cells (IC50) are shown as the mean ± SE of two independent experiments performed in triplicate.