. 2020 Mar 25;63(15):7923–7956. doi: 10.1021/acs.jmedchem.9b01245

Table 14. Chemical Structures and Inhibition of Biofilm Formation (IC₅₀, μg/mL) of Thiazole Derivatives 44a–l.

compd	R	R¹	R²	S. aureus ATCC 25923 (μg/mL)	S. aureus ATCC 6538 (μg/mL)	P. aeuriginosa ATCC 15442 (μg/mL)
44a	H	CH₂CH₂NHBoc	H	3.9 ± 0.2	5.2 ± 0.3	ns
44b	H	CH₂CH₂NH₂	H	4.7 ± 0.3	9.7 ± 0.9	22.7 ± 2.1
44c	Br	CH₂CH₂NH₂	H	4.4 ± 0.1	3.3 ± 0.08	7.8 ± 0.09
44d	F	CH₂CH₂NH₂	H	1.5 ± 0.1	6.3 ± 0.4	4.5 ± 0.4
44e	F	CH₂CH₂NH₂	CH₃	0.5 ± 0.02	5.2 ± 0.08	3.9 ± 0.07
44f	OCH₃	CH₂CH₂OCH₃	CH₃	1.2 ± 0.03	11.5 ± 0.7	ns
44g	Br	CH₂CH₂OCH₃	H	0.79 ± 0.009	9.4 ± 0.3	4.4 ± 0.08
44h	Br	CH₂CH₂OCH₃	CH₃	0.95 ± 0.01	11.2 ± 1.1	19.1 ± 0.1
44i	Br	CH₂CH₂OCH₃	CH₂CH₂OCH₃	2.9 ± 0.02	18.8 ± 1.5	ns
44j	Br	CH₃	CH₂CH₂OCH₃	2.5 ± 0.02	ns	ns
44k	F	CH₂CH₂OCH₃	CH₃	0.2 ± 0.006	21.0 ± 1.7	ns
44l	H	Boc	CH₂CH₂OCH₃	1.8 ± 0.1	6.9 ± 0.1	ns

Table 14. Chemical Structures and Inhibition of Biofilm Formation (IC50, μg/mL) of Thiazole Derivatives 44a–l.